The role played by alternative splicing in antigenic variability in

Por um escritor misterioso

Descrição

Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
The role played by alternative splicing in antigenic variability in
PDF) The role played by alternative splicing in antigenic
The role played by alternative splicing in antigenic variability in
Alternative mRNA splicing in cancer immunotherapy
The role played by alternative splicing in antigenic variability in
The Expanding Landscape of Alternative Splicing Variation in Human
The role played by alternative splicing in antigenic variability in
The relevance of alternative RNA splicing to pharmacogenomics
The role played by alternative splicing in antigenic variability in
Single-cell and long-read sequencing to enhance modelling of
The role played by alternative splicing in antigenic variability in
Bioconjugation Approaches to Producing Subunit Vaccines Composed
The role played by alternative splicing in antigenic variability in
Immunoglobulin class switching - Wikipedia
The role played by alternative splicing in antigenic variability in
mRNA splicing ~ ViralZone
The role played by alternative splicing in antigenic variability in
Frontiers Shared Mechanisms for Mutually Exclusive Expression
The role played by alternative splicing in antigenic variability in
The role played by alternative splicing in antigenic variability
The role played by alternative splicing in antigenic variability in
Alternative splicing of cell surface receptors in Homo sapiens
The role played by alternative splicing in antigenic variability in
Cancers, Free Full-Text
The role played by alternative splicing in antigenic variability in
RNA Dysregulation: An Expanding Source of Cancer Immunotherapy
de por adulto (o preço varia de acordo com o tamanho do grupo)