BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA
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Descrição
Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence
BRCA2 promotes DNA-RNA hybrid resolution at DNA breaks to facilitate homologous recombination
Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation
DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions. - Abstract - Europe PMC
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
R-loop resolution and formation in the cell. (A) Prevention and
Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5 - ScienceDirect
Genome Instability and Cancer Predisposition
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡
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