Casa
scp 7148

The role played by alternative splicing in antigenic variability

Por um escritor misterioso

Descrição
Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
The role played by alternative splicing in antigenic variability
Alternative splicing in cancer cells. Impact of splicing (left part)
The role played by alternative splicing in antigenic variability
Alternative splicing of apoptosis genes promotes human T cell survival
The role played by alternative splicing in antigenic variability
The Expanding Landscape of Alternative Splicing Variation in Human Populations - ScienceDirect
The role played by alternative splicing in antigenic variability
RNA splicing - Wikipedia
The role played by alternative splicing in antigenic variability
The role of alternative splicing in cancer: From oncogenesis to drug resistance - ScienceDirect
The role played by alternative splicing in antigenic variability
Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer - ScienceDirect
The role played by alternative splicing in antigenic variability
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
The role played by alternative splicing in antigenic variability
Figure 1 from Antigenic variation in African trypanosomes
The role played by alternative splicing in antigenic variability
Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health, Cell & Bioscience
The role played by alternative splicing in antigenic variability
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
The role played by alternative splicing in antigenic variability
Gene's Accession Number, DNA-based tools
The role played by alternative splicing in antigenic variability
The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
de por adulto (o preço varia de acordo com o tamanho do grupo)