Viruses, Free Full-Text

Por um escritor misterioso

Descrição

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, Flavivirus genus, is responsible for neurological symptoms that may cause permanent disability or death. With an incidence on the rise, it is the major arbovirus affecting humans in Central/Northern Europe and North-Eastern Asia. Neuronal death is a critical feature of TBEV infection, yet little is known about the type of death and the molecular mechanisms involved. In this study, we used a recently established pathological model of TBEV infection based on human neuronal/glial cells differentiated from fetal neural progenitors and transcriptomic approaches to tackle this question. We confirmed the occurrence of apoptotic death in these cultures and further showed that genes involved in pyroptotic death were up-regulated, suggesting that this type of death also occurs in TBEV-infected human brain cells. On the contrary, no up-regulation of major autophagic genes was found. Furthermore, we demonstrated an up-regulation of a cluster of genes belonging to the extrinsic apoptotic pathway and revealed the cellular types expressing them. Our results suggest that neuronal death occurs by multiple mechanisms in TBEV-infected human neuronal/glial cells, thus providing a first insight into the molecular pathways that may be involved in neuronal death when the human brain is infected by TBEV.
Viruses, Free Full-Text
Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations — United States, 2023
Viruses, Free Full-Text
How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case
Viruses, Free Full-Text
Viruses, Free Full-Text
Viruses, Free Full-Text
How to Check a Website for Viruses: 6 Methods
Viruses, Free Full-Text
How to Tell If You Have a Computer Virus
Viruses, Free Full-Text
Abstract Display Option Added For PubMed Labs Search Results. NLM Technical Bulletin. 2018 Sep–Oct
Viruses, Free Full-Text
Page 29 Chest Virus Images - Free Download on Freepik
Viruses, Free Full-Text
How to Remove Virus from Laptop or PC Without Antivirus - EaseUS
Viruses, Free Full-Text
Free Online Virus Scan
Viruses, Free Full-Text
Virus & threat protection in Windows Security - Microsoft Support
de por adulto (o preço varia de acordo com o tamanho do grupo)